Tuberculosis (TB) is the world’s top infectious killer. In 2017, 10 million people became ill with the disease and 1.6 million died. Each year, more than 3 million people with TB are left behind without effective treatment. Drug-resistant TB (DR-TB) is a public health crisis and a health security risk in many countries. Yet only one in seven people with DR-TB are being treated today. The global rate of decline of TB incidence—2% on average—is far short of targets established in WHO’s End TB Strategy. At the current rate of progress, the world will not be able to end TB align with the Sustainable Development Goals 2030.